Ceruloplasmin test

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Know more about Ceruloplasmin test

You may need this test if you have a family history of Wilson disease. You have to inherit a gene from both parents in order to have the disease, so it's possible to have this condition even without a known family history. Symptoms usually begin between ages 5 and 35. But they can appear earlier or later in life. You may also have this test if you have nerve problems and liver-related problems that look a lot like symptoms of hepatitis.

Signs and symptoms that a health practitioner suspects may be due to Wilson disease, such as: 

Anemia

Nausea, abdominal pain

Jaundice

Fatigue

Behavioral changes

Tremors

Difficulty walking and/or swallowing

Dystonia

A doctor will ask about your symptoms and ask for your family's medical history. They'll also use a variety of tests to look for damage caused by copper accumulations. 

Physical exam

During your physical, your doctor will: 

examine your body

listen for sounds in the abdomen

check your eyes under a bright light for K-F rings or sunflower cataracts

tests your motor and memory skills

Lab tests

For blood tests, your doctor will draw samples and have them analyzed at a lab to check for: 

 

abnormalities in your liver enzymes

copper levels in the blood

lower levels of ceruloplasmin, a protein that carries copper through the blood

a mutated gene, also called genetic testing

low blood sugar

Your doctor may also ask you to collect your urine for 24 hours to look for copper accumulation. 

You may want to drink distilled water because most tap water flows through copper pipes. Avoid using copper cooking utensils. Symptoms may be managed with exercise or physical therapy. People who are confused or unable to care for themselves may need special protective measures. A liver transplant may be considered in cases where the liver is severely damaged by the disease.

The goal of treatment is to reduce the amount of copper in the tissues. This is done by a procedure called chelation. Certain medicines are given that bind to copper and help remove it through the kidneys or gut. Treatment must be lifelong. 

 

The following medicines may be used: 

 

Penicillamine (such as Cuprimine, Depen) binds to copper and leads to increased release of copper in the urine. 

Trientine (such as Syprine) binds (chelates) the copper and increases its release through the urine. 

Zinc acetate (such as Galzin) blocks copper from being absorbed in the intestinal tract. 

Vitamin E supplements may also be used. 

Sometimes, medicines that chelate copper (such as penicillamine) can affect the function of the brain and nervous system (neurological function). Other medicines under investigation may bind copper without affecting neurological function. 

Test Method 1 : For the ceruloplasmin test, you'll be required to provide a blood sample. 

 

The blood sample is extracted through the arm by a needle. The blood will be collected in a tube and sent to a lab for analysis. 

 

Once the lab reports the results, your doctor will be able to provide you with more information about the results and what they mean. 

Report available : Turn around time is 24 hours. 

A person have the following signs and symptoms should get this done: 

 

Anemia

Nausea, abdominal pain

Jaundice

Fatigue

Behavioral changes

Tremors

Difficulty walking and/or swallowing

Dystonia

Wilson disease , copper storage disease, Menkes disease, Copper deficiency, Aceruloplasminemia