Creatinine And Its Formation
Creatinine is a waste byproduct of the body, it is good to know how is that formed and from where? To understand it better, the most important thing to know is Creatine. Creatine is a constituent of a normal diet of, protein-based foods, such as milk, meat, and nuts.
It is not, considered an essential nutrient because the kidneys, liver, pancreas, and possibly brain cells are able to synthesize this compound endogenously from the amino acids arginine, glycine, and It is estimated that approximately half of an individual’s daily requirement comes from alimentary creatine, while the remainder is replenished by the body. Creatine itself can be phosphorylated by enzyme creatine kinase to form phosphocreatine, which is used as an energy buffer in skeletal muscles and the brain. The breakdown product of phosphocreatine gives creatinine.
Creatinine is a waste product that is produced by the normal breakdown of muscle tissue. As creatinine is produced, it’s filtered through the kidneys and excreted in urine and reabsorb almost none of it. Doctors measure the blood creatinine level as a test of kidney function. The kidneys’ ability to handle creatinine is, called the creatinine clearance rate, which helps to estimate the glomerular filtration rate (GFR) — the rate of blood flow through the kidneys.
Creatinine clearance in a healthy young person is about 95 milliliters per minute for women and 120 milliliters per minute for men. This means that each minute, that person’s kidneys clear 95-120 ml of blood free of creatinine. The GFR can vary depending on age, sex, and size. Generally, the creatinine clearance is a good estimation of the glomerular filtration rate.
Creatinine Clearance an important indicator of Renal Function
Doctors use creatinine and creatinine clearance tests to check renal function (kidney function). Testing the rate of creatinine clearance shows the kidneys’ ability to filter the blood.
As renal function declines, creatinine clearance also goes down. Ways to measure creatinine clearance:
- Creatinine clearance can be precisely, determined by measuring the amount of creatinine present in a sample of urine collected over 24 hours. This method requires a person to place all his urine in a plastic jug for one day and bring it in for testing. Although the urine creatinine measurement method is inconvenient, it may be necessary to diagnose some kidney conditions.
- GFR can be, estimated using a single blood level of creatinine, the higher the blood creatinine level, the lower the, estimated GFR and creatinine clearance.
Recommended levels of Creatinine:
Accurate renal function measurements are important for the diagnosis and treatment of kidney disease.
Normal adult reference values: urinary excretion of creatinine is 0.5-2.0g per 24 hours in a normal adult, varying according to muscular weight.
Creatinine clearance :
90-140ml/min in males and 80-125ml/min in females
A raised serum creatinine is a good indicator of, impaired renal function. But normal serum creatinine does not necessarily indicate normal renal function a serum creatinine may not be, elevated until GFR has fallen by as much as 50%.
Serum creatinine is, used to monitor progression and treatment in acute kidney injury and chronic kidney disease (CKD). In acute kidney injury, the frequency of measurements will usually be, guided by clinical factors and the, need to monitor serum potassium but is unlikely to be less than once in 24 hr.
In patients with CKD 1-3 (i.e. eGFR ≥60 mL/min) measurements should be made at least once in 6-12 months accordingly whether the GFR is changing by more or less than 15ml/min. Respectively, between successive measurements; in patients with more, advanced CKD, the corresponding figures are 3-6months.
Serum creatinine can be, used together with demographic information (age, sex, and race) to calculate an estimated GFR. In foreign countries — it is, recommended that estimated GFR should be, based on the modification of diet in renal disease (MDRD).
Things to follow to keep creatinine in control:
One should take a proper care to keep the creatinine levels in normal range.
It is, suggested to do the following:
Too much of body work out may lead to increase creatinine levels as a response to increasing muscle break down.
Avoid creatine supplement:
As read above Creatine is a natural compound produced in our body. It is, transported to muscles where it is, used for energy. Unused creatine not used as energy converts into creatinine, a waste product. In addition to its natural form, creatine is also available as an oral supplement. Some athletes use these supplements to help enhance athletic performance. Just like natural creatine, supplements containing this substance produce creatinine. To reduce creatinine levels one should not take creatine supplements.
Reduce protein intake:
Eating large amounts of protein can increase creatinine levels, at least temporarily. Cooked red meat, in particular, can affect creatinine. The heat from cooking causes creatine found in meat to produce creatinine. People with diets very high in red meat or other protein sources, including dairy products, may have higher creatinine levels than people who eat less of those foods.
Increase fiber intake:
Foods like vegetables, fruits, legumes, and whole grains to be, taken.
Keep the body Hydrated:
Dehydration can lead to increase in creatinine levels. Increase in fluid intake can also be a problem with patients suffering from kidney impairment. It is, advised to follow the Doctors instructions.
Creatinine is important Biomarker of Kidney function. The increase in creatinine level indicates the decrease in kidney function. Repeated tests to estimate the level would help to diagnose the kidney functions better.